Interaction of a Non-Histone Chromatin Protein (High-Mobility Group Protein 2) with DNA

Does high-mobility-group non-histone protein HMG 1 interact specifically with histone H1 subfractions?

The interaction of the non-histone chromosomal protein HMG (high-mobility group) 1 with histone H1 subfractions was investigated by equilibrium sedimentation and n.m.r. sectroscopy. In contrast with a previous report [Smerdon & Isenberg (1976) Biochemistry 15, 4242--4247], it was found, by using equilibrium-sedimentation analysis, that protein HMG 1 binds to all three histone H1 subfractions CT...

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage.

High mobility group protein B1 (HMGB1) is a multifunctional protein with roles in chromatin structure, transcriptional regulation, V(D)J recombination, and inflammation. HMGB1 also binds to and bends damaged DNA, but the biological consequence of this interaction is not clearly understood. We have shown previously that HMGB1 binds cooperatively with nucleotide excision repair damage recognition...

Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein

The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific researches emerging within the past two decades suggest that immune dysfunction and inflammation have pathogenic influences through different mechanisms, all leading to both a chronic state of low ...

The isolation and identification of ubiquitin from the high mobility group (HMG) non-histone protein fraction.

Chromatin contains a group of non-histone chromosomal proteins called the high mobility group (HMG) proteins [l] . Four of the HMG proteins from calf thymus, HMG 1,2,14 and 17, and an HMG protein from trout testis, HMG-T, have been isolated in a pure form [2-51. The amino acid sequence of calf thymus HMG 17 has recently been determined [6] , and we have also shown that HMG proteins HMG 1,2, 14 ...

HMGIY (high mobility group protein (non histone chromosomal) isoform I and Y)